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lmrA [2017-12-15 18:22:48]
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lmrA [2017-12-15 18:22:48]

transcriptional regulator (TetR family), control of qdoI-yxaH and lmrA-lmrB
locus
BSU02680
pI
5.03
mw
20.52 kDa
protein length
188 aa Sequence Blast
gene length
564 bp Sequence Blast
function
regulation of lincomycin resistance
product
transcriptional regulator
essential
no
synonyms
lin-2, yccB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]

    • Gene

    Coordinates
    290,132 → 290,698

    The protein

    Protein family

  • [SW|TetR family]

    • Paralogous protein(s)

  • [protein|47387014B5E89BF218BA94D8C2A570479B1EFD4E|QdoR]

    • Effectors of protein activity

  • flavonoids such as quercetin serve as inducers, binding results in release from DNA [Pubmed|17483215]

    • Expression and Regulation

    Operons

    genes
    [gene|52D560AA02F0849CB24460A496021560063B2E12|lmrA]-[gene|23483430AE0381406EF2349A18CFAE1F14F9B180|lmrB]
    description
    [Pubmed|15317768]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|12499232], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|52D560AA02F0849CB24460A496021560063B2E12|LmrA]: repression, [Pubmed|15317768], in [regulon|52D560AA02F0849CB24460A496021560063B2E12|LmrA regulon]

    • regulation

  • induced by flavonoids such as quercetin ([protein|search|LmrA])[Pubmed|17483215]

    • additional information

  • the mRNA is substantially stabilized upon depletion of [gene|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [PubMed|21815947]
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    Biological materials

    Mutant

  • BKE02680 (Δ[gene|52D560AA02F0849CB24460A496021560063B2E12|lmrA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE02680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAACATTCCCACCTTACT, downstream forward: _UP4_TAAAAAAAACGACATACTAC
  • BKK02680 (Δ[gene|52D560AA02F0849CB24460A496021560063B2E12|lmrA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK02680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAACATTCCCACCTTACT, downstream forward: _UP4_TAAAAAAAACGACATACTAC

    • References

    Reviews

  • 24006471,25209494

    • Original publications

  • 15317768,17483215,12499232,21815947